Detecting Chemosensitivity and Predicting Treatmemt Efficacy With CTCs in mNPC

  • days left to enroll
  • participants needed
  • sponsor
    Sun Yat-sen University
Updated on 20 August 2021
iv infusion
chemotherapy regimen
administration intravenous


The prospective observational clinical study will recruit 50 metastatic nasopharyngeal carcinoma (mNPC) patients, detecting patient's chemosensitivity with the circulating tumor cells (CTCs) from peripheral blood and prdicting patient's treatment efficacy with CTCs dynamic change.

Condition Advanced Malignancies, Liver Metastases, Metastatic Cancer, Nasopharyngeal Cancer, Metastasis, Effects of Chemotherapy, Vulvar Dysplasia and Carcinoma, Neoplasm Metastasis, Distant Metastases.Clinical, Carcinoma, Tumor embolus, Brain Metastases, Bone Metastases, nasopharyngeal carcinoma
Treatment cisplatin-based chemotherapy
Clinical Study IdentifierNCT04544969
SponsorSun Yat-sen University
Last Modified on20 August 2021


Yes No Not Sure

Inclusion Criteria

NPC patients with distant metastasis after 3 months of primary radiotherapy, and not suitable for local treatment
At least having one measurable metastatic lesion
All gendersrange from 1870 years old
ECOG score 0 ~ 1
Expected survival time 3 months
White blood cell(WBC) count 3109/L, neutrophile granulocyte(NE) count 1.5109/L, hemoglobin(HGB) 90g/L, platelet(PLT) count 100109/L
Alanine aminotransferase (ALT) or aspartate aminotransferase(AST) < 2.5upper limit of normal(ULN), bilirubin(BUN) or creatinine(CRE) < 1.5ULN, alanine aminotransferase (CCR) 60ml/min
Inform consent form

Exclusion Criteria

Have or are suffering from other malignant tumors
Participating in other clinical trials
Drug or alcohol addition
Do not have full capacity for civil acts
Mental disorder
Pregnancy or lactation
Severe complication, eg, uncontrolled hypertension
Clear my responses

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