The Occurrence of Single Nucleotide Polymorphism Among Women Who Experienced Obstetric Anal Sphincter Injury

  • STATUS
    Recruiting
  • End date
    Mar 16, 2022
  • participants needed
    150
  • sponsor
    HaEmek Medical Center, Israel
Updated on 16 July 2021

Summary

Single-nucleotide polymorphisms (SNP's) in connective tissue components are associated with increased risk of pelvic organ prolapse (POP). The investigators expect to find a difference in SNP's frequency between women who had Obstetric anal sphincter injuries (OASIS) and in the healthy population. The fact that pelvic organ prolapse (POP) and OASIS occurs in the same anatomic region and the well-known association between few SNP's and the risk for POP, suggests for a common pathophysiology.

Description

The perineum consists of skin, muscles and connective tissue. A connective tissue disorder related to POP has been reported in biochemical and molecular studies. OASIS are considered a severe complication of vaginal delivery that may lead to a great deal of morbidity. Familial history is known as a risk factor for OASIS. Currently, there is no established genetic link between connective tissue components and OASIS. Therefore, the investigators assume that studying the genetic predisposition factors of women who experience OASIS, might generate a stronger tool to predict severe occurrence of vaginal laceration. It may also help to consult women before vaginal delivery about the risk of OASIS.

The aim of this study is to find an association between genetic variation and increased risk for OASIS.

Details
Condition Delivery
Treatment Whole exome sequencing, screening for single nucleotide polymorphism
Clinical Study IdentifierNCT04047433
SponsorHaEmek Medical Center, Israel
Last Modified on16 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women with severe external anal sphincter injury during first vaginal delivery
Healthy women undergoing vaginal delivery without any clinically apparent perineal laceration

Exclusion Criteria

Women with known metabolic or connective-tissue disorder (e.g., Ehlers-Danlos syndrome)
Women with known neurologic disorder
Women undergoing episiotomy cut or assisted delivery (e.g., vacuum or forceps delivery)
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