To Assess the Efficacy and Safety of INCB054707 in Participants With Hidradenitis Suppurativa

  • End date
    Sep 27, 2022
  • participants needed
  • sponsor
    Incyte Corporation
Updated on 4 August 2021


To evaluate the efficacy and safety of INCB054707 in participants with hidradenitis suppurativa over a 16-week placebo-controlled treatment period followed by a 36 -week open-label extension period.

Condition Hidradenitis Suppurativa, Acne Inversa
Treatment Placebo, INCB054707
Clinical Study IdentifierNCT04476043
SponsorIncyte Corporation
Last Modified on4 August 2021


Yes No Not Sure

Inclusion Criteria

HS disease duration of at least 3 months before screening
Willingness to avoid pregnancy or fathering children
Active HS in at least 2 distinct anatomical areas
Participants agree NOT to use topical antiseptics on the areas affected by HS lesions during the placebo-controlled 16-week treatment period

Exclusion Criteria

Draining fistula count of > 20 at screening or baseline
Women who are pregnant (or who are considering pregnancy) or lactating
Medical history including thrombocytopenia, coagulopathy or platelet dysfunction, Q-wave interval abnormalities, current or history of certain infections, cancer, lymphoproliferative disorders and other medical conditions at the discretion of the investigator
History of failure to treatment of inflammatory diseases with JAK inhibitors
Have evidence of active or latent or inadequately treated infection with Mycobacterium tuberculosis
Participants known to be infected with HIV, Hepatitis B, or Hepatitis C
Laboratory values outside of the protocol-defined ranges
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