A Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsule Versus Sunitinib in Subjects With Advanced Renal Cancer

  • STATUS
    Recruiting
  • End date
    Jun 25, 2023
  • participants needed
    418
  • sponsor
    Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Updated on 25 January 2021

Summary

This study is a randomized, positive parallel controlled, multicentre phase III clinical trial to evaluate the efficacy and safety of TQB2450 combined with anlotinib versus sunitinib in subjects with advanced renal cancer.

Details
Condition Advanced Renal Cancer
Treatment Sunitinib, Anlotinib, TQB2450
Clinical Study IdentifierNCT04523272
SponsorChia Tai Tianqing Pharmaceutical Group Co., Ltd.
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 80 yrs?
Gender: Male or Female
Do you have Advanced Renal Cancer?
Do you have any of these conditions: Do you have Advanced Renal Cancer??
\. Histopathologically confirmed renal clear cell cancer, including advanced renal cell carcinoma with clear cell components. 2. Has not receiving systemic therapy for local advanced/metastatic disease. 3. At least has one measurable lesion. 4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1; Life expectancy 3 months. 5. Adequate laboratory indicators. 6. Agree to provide at least 5 slices tumor tissue samples for biomarker detection. 7. Serum or urine pregnancy tests are negative within 7 days before randomization; Men and women should agree to use effective contraception during the study period and after the end of the study period within 6 months. 8. Understood and signed an informed consent form

Exclusion Criteria

\. Has symptomatic central nervous system (CNS) disease and / or cancerous meningitis, pia mater disease. 2. Has received anti-angiogenesis targeted therapy or targeted PD-1 and PD-L1 immunotherapy. 3. Has active virus, bacteria, fungal infection; Cardiovascular and cerebrovascular diseases; Gastrointestinal abnormalities; Immunodeficiency; Bleeding risk; Lung disease; Neurological or psychiatric disorders. 4. Has participated in other clinical trials within 30 days before randomization. 5. Has received attenuated live vaccine within 28 days before randomization or planned to received attenuated live vaccine during the study period. 6. Pregnant or lactating women. 7. According to the judgement of the investigators, there are other factors that may lead to the termination of the study
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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