Skin Barrier Assessment in Pregnancy and at Birth

  • participants needed
  • sponsor
    National Jewish Health
Updated on 3 July 2022
food allergy


This is a prospective birth cohort study assessing the role of maternal and environmental factors on the development of allergic diseases in children. Pregnant mothers will be enrolled and we will examine her skin barrier with skin tape strips (STS) and transepidermal water loss (TEWL), along with blood work. We will then follow her offspring and perform similar testing, along with detailed questionnaires inquiring about exposures such as use of detergents and soaps, sunlight exposure, and pollution exposure. When the infant is around 12 months old, we will contact the family via telephone to see if the child developed any allergic conditions within their first year of life, such as eczema, food allergy, or wheezing. A final questionnaire will be performed.

Condition Immunology, Hypersensitivity, Allergy, Allergy (Pediatric), Food Allergy, Allergy (Pediatric), Pregnancy Related, Childhood Asthma, Atopic Dermatitis Eczema, Asthma in Children, Allergy, atopic dermatitis/eczema, allergic response, food allergies
Treatment Blood draw, Skin tape stripping, TransEpidermal Water Loss, Bacterial PCR swab
Clinical Study IdentifierNCT04445298
SponsorNational Jewish Health
Last Modified on3 July 2022

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