Statins in Reducing Events in the Elderly (STAREE) Heart Sub-study

  • End date
    Dec 26, 2022
  • participants needed
  • sponsor
    Monash University
Updated on 26 January 2021
diagnostic procedure
12 lead ECG
heart study
hmg-coa reductase inhibitors


The STAREE-HEART sub-study will examine the effect of statin treatment over a 3-year period compared with placebo on markers of cardiac ageing. This will include determining global longitudinal strain with transthoracic echocardiography, atrial fibrillation with home measures twice daily for two weeks and changes in biomarkers.


STAREE-HEART is a sub-study nested in the Statins in Reducing Events in the Elderly (STAREE) double-blind randomised placebo-controlled trial. STAREE is investigating whether statins can prolong good health and maintain independence amongst older people and is enrolling men and women 70 years of age and over who are free from cardiovascular disease, diabetes and dementia. STAREE-HEART will recruit a subset of 1000 STAREE participants before they are randomised to STAREE study drug. STAREE-HEART will involve an additional suite of cardiac assessments in these participants and will provide detailed information about the clinical effect of statins on incidence of atrial fibrillation and heart failure.

Condition Hypercholesterolemia, Arrhythmia, Dysrhythmia, Arrhythmia, Atrial Fibrillation, Atrial Fibrillation, Atrial Fibrillation (Pediatric), Heart failure, Congestive Heart Failure, Heart failure, Heart disease, Heart disease, Cardiac Disease, Hyperlipidemia, High Cholesterol (Hyperlipidemia), High Cholesterol (Hyperlipidemia), Atrial Fibrillation (Pediatric), Healthy Ageing, High Cholesterol, Congestive Heart Failure, Dysrhythmia, Cardiac Disease, elevated cholesterol, hypercholesteremia, cardiac failure, congestive heart disease
Treatment Echocardiography, ECG screening
Clinical Study IdentifierNCT04536870
SponsorMonash University
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Men and women aged 70 years living independently in the community who are participants in the STAREE RCT and eligible for randomisation to study medication
Willing and able to provide informed consent and accept the STAREE-HEART study requirements, including attendance for an echocardiogram and undertaking home monitoring via ECG

Exclusion Criteria

Known atrial fibrillation or atrial flutter
Participants who do not wish to be informed of an abnormality under any circumstances, regardless of severity, will not be enrolled in the study
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