ICCAC-ToNF & Tinnitus

  • End date
    Dec 31, 2021
  • participants needed
  • sponsor
    University of Zurich
Updated on 25 January 2021


Prevalence of chronic subjective tinnitus is rising with age and associated with maladaptive oscillatory changes in auditory as well as non-auditory regions of the brain such as the insula and the anterior cingulate cortex which are known to be key points within the salience and distress networks of the brain.Thus, we are conducting a clinical trial by implementing those auditory as well as non-auditory regions into a tomographical neurofeedback Training (ToNF) -protocol.

Prior to 12 electroencephalography (EEG) -based ToNF-trainings with 36 older participants using standardized Low Resolution Electromagnetic Tomography Software (sLORETA, Pascual-Marqui 2002), participants' brains will be measured using structural magnet resonance imaging (sMRI) in order to identify potential structural markers for training success (e.g. cortical thickness).

Training success will be measured by oscillatory change via EEG before and after the training period as well as by means of follow-up measures. Furthermore, a comprehensive battery of behavioral and psychometric standardized self-report questionnaires will be applied.

Based on this multifocal (Insula, dorsal anterior cingulate cortex & auditory cortex) ToNF we expect oscillatory changes resulting in decreased tinnitus symptoms such as perceived loudness and distress.

Condition Tinnitus
Treatment tomographic EEG Neurofeedback Training
Clinical Study IdentifierNCT03895047
SponsorUniversity of Zurich
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

chronic tinnitus (>6 months)
Age 40 to 80
Informed Consent
Fluent in German language
mentally & physically fit

Exclusion Criteria

ferromagnetic implants
cochlear implants
average hearing loss over 50 dB
addiction to alcohol or drugs
intake of anesthetics, tranquilizers, neuroleptics or antiepileptics
acute suicidal
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