Pituitary Adenoma and Serum Lipid

  • STATUS
    Recruiting
  • End date
    Jun 27, 2024
  • participants needed
    1000
  • sponsor
    Shandong Provincial Hospital
Updated on 27 May 2022

Summary

Pituitary adenomas are usually benign monoclonal neoplasms caused by a mixture of pituicyte alterations together with a changed endocrine and paracrine regulatory milieu. Thus, it can cause serious health problems such as abnormal target organ function, pain, disability and even death. In clinical practice, we found many patients with pituitary adenomas are usually accompanied by hyperlipidemia, which is the main cause of cardiovascular diseases. However, it has been unclear if there is an association between pituitary adenomas and serum lipid profile. In the present study, we aim to focus on the patients with pituitary adenomas and their lipid profile before and after operation including first occurrence and recurrence.

Details
Condition Pituitary Adenoma 1, Acth-Secreting
Clinical Study IdentifierNCT04021212
SponsorShandong Provincial Hospital
Last Modified on27 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients diagnosed with pituitary adenomas
All adenomas were resected by transsphenoidal surgery and identified by histological diagnoses

Exclusion Criteria

Missing vital data, such as age, gender, serum lipid profile, pathology reports
Complications or conditions that affect pituitary status and lipid metabolism, such as pregnancy, malignant adenomas or severe hepatic or renal dysfunction and
Use of any medication that affects the pituitary or lipid metabolism, including statins, fibrates, thyroid hormones, anti-thyroid drugs, iodine, amiodarone, alemtuzumab, lithium, tyrosine kinase inhibitors, interferon, estrogens, androgens,glucocorticoids, nonsteroidal anti-inflammatory drugs, antiepileptic drugs, rifampicin, furosemide, heparin or β-adrenoceptor blockers in the past 3 months
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