Propacetamol to Reduce Post Cesarean Section Uterine Contraction Pain

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  • sponsor
    Mackay Memorial Hospital
Updated on 25 January 2021


To evaluate that perioperative regular usage of propacetamol to reduce post cesarean section uterine contraction pain and opioid consumption


The most common method of pain control after cesarean section is intravenous patient-control analgesia (IVPCA) with morphine. Multimodal analgesia could improve the quality of perioperative pain control and reduceside effects of opioids. Previous researches marked that perioperative pain after cesarean section includes somatic wound pain and visceral uterine contraction pain.

According to Academy of Breastfeeding Medicine, propacetamol is a safe pain-killer for an expectant mother and almost free from breast milk after intravenous injection. This study is a prospective double-blind randomized-controlled trial to evaluate that propacetamol could reduce visceral uterine contraction pain after cesarean section. Post cesarean section women will divide into three groups:

  1. pain control with IVPCA for 2 days
  2. pain control with IVPCA and propacetamol 1g every 6 hours for 2 days
  3. pain control with IVPCA and propacetamol 2g every 6 hours for 2 days

Condition Uterine Pain
Treatment Propacetamol 1g, Propacetamol 2g, IVPCA
Clinical Study IdentifierNCT03878082
SponsorMackay Memorial Hospital
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Pregnancy more than 36 weeks which is expected to receive Caesarean section
Post Caesarean section woman, age greater than or equal to 20 years old
ASA physical status class 1 or 2

Exclusion Criteria

ASA physical status class 3 or above
Less than 20 years old
Past caesarean section for longitudinal wounds
Undergone major abdominal surgery
Chronic pain
Allergic to morphine or Propacetamol
Liver dysfunction
Treatment with anticoagulant
Emergency operation
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