Cardiovascular Reserve Evaluation in Survivors of Transplant CREST Study

  • participants needed
  • sponsor
    City of Hope Medical Center
Updated on 2 October 2022
myelodysplastic syndromes
multiple myeloma
acute leukemia
cardiopulmonary exercise testing


This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.



I. Evaluate cardiovascular reserve capacity, as measured by peak oxygen consumption (VO2peak), in hematopoietic cell transplantation (HCT) survivors.

II. Define the determinants of VO2peak impairment in HCT survivors.


Patients undergo echocardiogram to assess cardiac function and mechanics, cardiopulmonary exercise test, pulmonary function test, musculoskeletal ultrasound, bioelectrical impedance analysis to measure total lean body mass and percent body fat), physical function tests, and collection of blood samples within 45 days from the start of conditioning therapy, and at 6 months, 1 year, and 2 years post-transplant.

Condition Bone marrow disorder, Bone marrow disorder, childhood ALL, Lymphocytic Leukemia, Acute, Hodgkin's Disease, Hodgkin's Disease, Hematologic Malignancy, Blood Cancer, Hematologic Cancer, Hematologic Neoplasms, Multiple Myeloma, Multiple Myeloma, Lymphoma, Non-Hodgkin's Lymphoma, Preleukemia, Acute myeloid leukemia, Acute Myelogenous Leukemia (AML), Acute myeloid leukemia, Lymphoproliferative Disorder, Lymphoproliferative disorders, Lymphoma, MYELODYSPLASTIC SYNDROME, Myelodysplastic Syndromes (MDS), Non-Hodgkin's Lymphoma, Myelodysplastic Syndromes (MDS), Acute Myelogenous Leukemia (AML), Lymphocytic Leukemia, Acute, Blood Cancer, Hematologic Cancer, Hematologic Neoplasms, Lymphoproliferative disorders, acute lymphoblastic leukemia, hematopoietic and lymphoid cell neoplasm, leukemia, acute lymphoblastic, myelodysplastic syndromes, non-hodgkin's lymphoma (nhl), multiple myeloma (mm), myelodysplastic syndrome (mds), hodgkin, hodgkin's lymphomas, hodgkin lymphomas, hodgkins lymphoma, hodgkin's lymphoma, acute lymphoid leukaemia, acute lymphocytic leukemia, acute lymphoblastic leukemia (all), acute myelogenous leukemia, anll, acute myeloblastic leukemia, hematopoietic malignancy
Treatment questionnaire administration, Echocardiography, biospecimen collection, ultrasound, Physical Performance Testing, Cardiopulmonary exercise testing, bioelectric impedance analysis, Pulmonary function test
Clinical Study IdentifierNCT04537871
SponsorCity of Hope Medical Center
Last Modified on2 October 2022

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note