Cardiovascular Reserve Evaluation in Survivors of Transplant CREST Study

  • STATUS
    Recruiting
  • participants needed
    350
  • sponsor
    City of Hope Medical Center
Updated on 2 October 2022
lymphoma
myelodysplastic syndromes
multiple myeloma
acute leukemia
leukemia
cardiopulmonary exercise testing

Summary

This study evaluates how well the heart, lungs, and muscles are working individually, and how these systems are working together in transplant survivors. Information collected in this study may help doctors to understand why hematopoietic stem cell transplant survivors are at higher risk for developing cardiovascular disease.

Description

PRIMARY OBJECTIVES:

I. Evaluate cardiovascular reserve capacity, as measured by peak oxygen consumption (VO2peak), in hematopoietic cell transplantation (HCT) survivors.

II. Define the determinants of VO2peak impairment in HCT survivors.

OUTLINE

Patients undergo echocardiogram to assess cardiac function and mechanics, cardiopulmonary exercise test, pulmonary function test, musculoskeletal ultrasound, bioelectrical impedance analysis to measure total lean body mass and percent body fat), physical function tests, and collection of blood samples within 45 days from the start of conditioning therapy, and at 6 months, 1 year, and 2 years post-transplant.

Details
Condition Bone marrow disorder, Bone marrow disorder, childhood ALL, Lymphocytic Leukemia, Acute, Hodgkin's Disease, Hodgkin's Disease, Hematologic Malignancy, Blood Cancer, Hematologic Cancer, Hematologic Neoplasms, Multiple Myeloma, Multiple Myeloma, Lymphoma, Non-Hodgkin's Lymphoma, Preleukemia, Acute myeloid leukemia, Acute Myelogenous Leukemia (AML), Acute myeloid leukemia, Lymphoproliferative Disorder, Lymphoproliferative disorders, Lymphoma, MYELODYSPLASTIC SYNDROME, Myelodysplastic Syndromes (MDS), Non-Hodgkin's Lymphoma, Myelodysplastic Syndromes (MDS), Acute Myelogenous Leukemia (AML), Lymphocytic Leukemia, Acute, Blood Cancer, Hematologic Cancer, Hematologic Neoplasms, Lymphoproliferative disorders, acute lymphoblastic leukemia, hematopoietic and lymphoid cell neoplasm, leukemia, acute lymphoblastic, myelodysplastic syndromes, non-hodgkin's lymphoma (nhl), multiple myeloma (mm), myelodysplastic syndrome (mds), hodgkin, hodgkin's lymphomas, hodgkin lymphomas, hodgkins lymphoma, hodgkin's lymphoma, acute lymphoid leukaemia, acute lymphocytic leukemia, acute lymphoblastic leukemia (all), acute myelogenous leukemia, anll, acute myeloblastic leukemia, hematopoietic malignancy
Treatment questionnaire administration, Echocardiography, biospecimen collection, ultrasound, Physical Performance Testing, Cardiopulmonary exercise testing, bioelectric impedance analysis, Pulmonary function test
Clinical Study IdentifierNCT04537871
SponsorCity of Hope Medical Center
Last Modified on2 October 2022

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