Nutritional Stimulation of Growth in Children With Short Stature

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    30
  • sponsor
    University of Arkansas
Updated on 29 September 2021

Summary

Short stature is a frequent reason for referral to a pediatric endocrinology clinic. Short stature is especially prevalent among those with failure to thrive (whose weight is significantly below the average weight of his/her peers). The growth hormone has limited efficacy for medical treatment of short stature when the cause of short stature is not growth hormone deficiency. This study will investigate the effect of 6 months of nutritional supplement (essential amino acids) compared to placebo in the linear growth of short children who have not yet reached puberty.

Details
Condition Failure to Thrive, Nutritional Stunting, growth failure
Treatment Placebo, Essential Amino Acid (EAA) group
Clinical Study IdentifierNCT04226586
SponsorUniversity of Arkansas
Last Modified on29 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Ages 3 to 11 years (inclusive)
Pre-pubertal status (i.e. Tanner stage 1 for breast development for girls and testicular enlargement for boys and pubic hair for both sexes)

Exclusion Criteria

Ages younger than 3 years or older than 11 years
Medical history of a neurologic, endocrinologic, genetic, or metabolic problem known to have a direct effect on height growth. This includes, but is not limited to, children with a Growth hormone deficiency, Down syndrome, Turner syndrome, Russel-Silver syndrome, Prader-Willi syndrome, Pseudohypoparathyroidism, chronic kidney disease, malabsorptive syndromes, cancer survivors, etc
Currently being treated or previously treated with Growth hormone, or history of oral steroid treatment within the last 3 months
Being in puberty
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