Proteins and Brain Networks in Atypical Alzheimer's Disease

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Updated on 24 January 2022
positron emission tomography
Accepts healthy volunteers


Participants will take part in 2-4 study visits including detailed history and neurological exam, pen-&-paper cognitive testing, and functional MRI and PET scans designed to help us understand how different forms of Alzheimer's disease affect brain circuits over time.


The purpose of this research study is to find out how Alzheimer’s disease, including less common forms of it, affects brain networks, how the Alzheimer’s protein tau spreads in the brain, and how tau and disrupted brain networks relate to your abilities on tests of memory and thinking. Brain networks can be measured with magnetic resonance imaging (MRI). Tau is a protein that builds up abnormally in Alzheimer’s disease and can be measured with positron emission tomography (PET) scanning. We are currently recruiting people ages 40-90 from the following groups: - people with mild cognitive impairment (MCI) - people with posterior cortical atrophy - people with logopenic aphasia - people with amnestic Alzheimer’s disease (typical Alzheimer’s disease) - people who are healthy What does participation entail? You will first come for a medical screening involving a history and physical, neurological exam, and some questionnaires. In a subsequent visit, you will undergo magnetic resonance imaging (MRI) of your brain and perform some cognitive tests. Some participants will be invited to have 1-2 positron emission tomography (PET) scans to detect levels of amyloid and tau (Alzheimer’s proteins) in regions of your brain. Compensation is up to $625 for each year

Condition Alzheimer's Disease, Alzheimer's Disease, Mild Cognitive Impairment, *Healthy Volunteers
Clinical Study IdentifierTX251282
Last Modified on24 January 2022


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Inclusion Criteria

You may not be eligible for the study if you have tested negative for amyloid in spinal fluid or on a PET scan in the past, you have another neurological or medical condition that could affect your thinking, you have metal implants or other metal in your body that could make an MRI unsafe, or you are taking certain medications that could affect your thinking
Study Schedule
The study schedule includes 2-4 visits over a 2-3 month period consisting of the following: 1) Consents, medical screening, bloodwork - approximately 2 hours 2) MRI scan and cognitive tests - approximately 2-3 hours. 3 and 4) Amyloid and tau PET scans, typically done in a single 4-6 hour session or in two shorter sessions, depending on scheduling. Participants are invited to return 18-24 months after their initial study visits to complete a set of follow-up visits similar to the initial visits
Study activities may include
A neurological history and exam with a doctor, pen & paper questionnaires about your symptoms, pen & paper cognitive tests, a blood draw, an magnetic resonance imaging (MRI) of the brain, positron emission tomography (PET) scans designed to detect levels of amyloid and tau (Alzheimer’s proteins) in regions of the brain
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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