Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery

  • End date
    Mar 14, 2027
  • participants needed
  • sponsor
    Helsinki University Central Hospital
Updated on 14 June 2021
antibiotic therapy
bowel preparation
rectal surgery


MOBILE2 is a randomized controlled trial comparing mechanical and oral antibiotic bowel preparation to mechanical bowel preparation only in patients undergoing anterior rectal resection with primary anastomosis. Primary endpoint is Comprehensive Complication Index within 30 days from surgery.

Condition Rectal Adenocarcinoma, rectal carcinoma, rectal neoplasms, colorectal cancers, colorectal tumor, Adenocarcinoma of Rectum, colorectal neoplasm, rectal neoplasm, rectal tumor, Colon Cancer Screening, Rectal disorder, Postoperative Wound Infection, Surgical Site Infection, Colon cancer; rectal cancer, Colorectal Cancer, Surgical Site Infections, cancer, colorectal, Rectal Cancer, tumors, colorectal, Surgery--Complications, Rectal Disorders, surgical wound infection
Treatment Placebo, mechanical bowel preparation, Oral Antibiotics
Clinical Study IdentifierNCT04281667
SponsorHelsinki University Central Hospital
Last Modified on14 June 2021


Yes No Not Sure

Inclusion Criteria

Patients scheduled for anterior rectal resection with primary anastomosis

Exclusion Criteria

Emergency operation
Bowel obstruction
Existing stoma
Other reason preventing mechanical bowel preparation
Allergy to neomycin or metronidazole
Age < 18 years
Lack of co-operation
Exclusion criteria after randomization
Patient did not undergo surgery
Anterior resection was not performed
Colonic anastomosis was not performed
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