Outcomes of MF Patients Exposure to Ruxolitinib During Transplantation

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Updated on 5 May 2022


Increasing experience of Ruxolitinib pre-allo SCT and data concerning Ruxolitinib during transplantation

  1. Diagnosis MF(includ Post-ET,Post-PV,PMF,MDS/MPN with MF)
  2. With at least two month Ruxolitinib treatment prior to transplantation
  3. DAC+BF as myeloablative conditioning regimen
  4. CSA from day -3 and MMF from day +1 until day 28 ATG Neovii® at dose of 7.5mg/KG for mismatch donor
  5. received Rux at +6d in ASCT and continued to +60d

Condition Time of Hematopoietic Reconstruction
Treatment comprehensive treatment regimen
Clinical Study IdentifierNCT04526223
Last Modified on5 May 2022


Yes No Not Sure

Inclusion Criteria

Age 18-60 years old, gender is not limited
Diagnosis MF(includ Post-ET,Post-PV,PMF) according to 2016 WHO
With at least two month Ruxolitinib treatment before transplantation
Informed consent of the patient or his legal representative

Exclusion Criteria

HCT-CI score≥2
Woman who is pregnant or nursing
MPN Patients who have received allogeneic hematopoietic stem cell transplantation
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