Exercise Capacity of Patients With Dermatomyosis

  • STATUS
    Recruiting
  • End date
    Jan 1, 2025
  • participants needed
    45
  • sponsor
    University Hospital, Strasbourg, France
Updated on 19 September 2021
weakness
muscle biopsy
creatine kinase
dermatomyositis
polymyositis
myopathy

Summary

Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown.

The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.

Details
Condition Dermatomyositis, CONNECTIVE TISSUE DISEASE, Dermatosis, Polymyositis, Dermatomyositis (Connective Tissue Disease), Congenital Skin Diseases, Polymyositis (Inflammatory Muscle Disease), Skin Conditions, Connective Tissue Diseases
Treatment exploration
Clinical Study IdentifierNCT03293615
SponsorUniversity Hospital, Strasbourg, France
Last Modified on19 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Woman or man> 18 years
Signature of informed consent
Muscle biopsy for suspicion of recent inflammatory myopathy (<6 months) or for exclusion of neuromuscular pathology
Prospectively, following the results of the muscle biopsy, the subjects will
divided into three groups meeting the following criteria
DM" group: DM according to the ENMC criteria
other inflammatory myopathy" group: polymyositis, autoimmune necrotizing myopathy, non-specific myositis or inclusion myositis according to the ENMC criteria
Group "no neuromuscular pathology": i) myalgia and / or intolerance to exercise and ii) normal neuromuscular examination, iii) no increase in blood creatine kinase level, iv) absence of electromyographic abnormality, v) histological Muscle mass

Exclusion Criteria

\- Taking an immunomodulatory treatment within 6 months before inclusion
Paraneoplastic form of the disease
Presence of associated interstitial pneumonitis
Neuromuscular pathology different from inflammatory myopathy
Unbalanced cardiovascular disease
Impossibility of giving the subject informed information (subject in an emergency situation, difficulty in understanding the subject, ...)
Subject under safeguard of justice
Subject under tutelage or under curators
Pregnancy (positive pregnancy test)
Breastfeeding
Clear my responses

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