Electroencephalography (EEG) Predictors of Transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD)

  • End date
    Dec 20, 2022
  • participants needed
  • sponsor
    Shanghai Mental Health Center
Updated on 20 September 2021
transcranial direct current stimulation


This study is designed to find Electroencephalogram (EEG) biomarkers to predict transcranial direct current stimulation (tDCS) response in obsessive-compulsive disorder.


The purpose of this study is to explore resting state electroencephalography and transcranial magnetic stimulation and electroencephalography (TMS-EEG) biomarkers that would predict transcranial direct current stimulation (tDCS) response in obsessive-compulsive disorder with cathode electrode targeting orbitofrontal cortex (OFC). 30 OCD patients will be recruited to this study and performed once a day, five times a week direct current stimulation treatment for two weeks. The investigators will assess symptom severity before and after two weeks of tDCS. Through the study, Yale-Brown Obsessive Compulsive ScaleY-BOCS, the Obsessive Compulsive Inventory-Revised (OCI-R), the Beck Depression Inventory-II (BDI-II), Pittsburgh sleep quality index (PSQI)and side-effect questionnaire will be obtained by a trained investigator. Resting state electroencephalography and TMS-EEG testing will be conducted before and after tDCS treatment.

Condition Generalized Anxiety Disorder (GAD), ANXIETY NEUROSIS, Anxiety Disorders, obsessive compulsive disorder, Anxiety Disorders (Pediatric), Generalized Anxiety Disorder (GAD - Pediatric), Obsessive-Compulsive Disorder
Treatment High-Definition Transcranial Direct Current Stimulation
Clinical Study IdentifierNCT04426773
SponsorShanghai Mental Health Center
Last Modified on20 September 2021


Yes No Not Sure

Inclusion Criteria

age: 18-50 years old
DSM-5 criteria for OCD
Y-BOCS total score > or = 16
>or9 years education

Exclusion Criteria

any additional current psychiatric comorbidity
The inability to receive tDCS because of metallic implants, or history of seizureshistory of head injury, or history of neurosurgery
Participants with claustrophobic, heart pacemaker, mechanical heart valve, mechanical implant such as an aneurysm clip, hip replacement, or any other pieces of metal that have accidentally entered their body
Any current significant medical condition
serious suicide risk
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