Study of ET140203 T Cells in Adults With Advanced Hepatocellular Carcinoma (ARYA-1)

  • participants needed
  • sponsor
    Eureka Therapeutics Inc.
Updated on 21 September 2023
platelet count
measurable disease
neutrophil count
alpha fetoprotein
hepatocellular carcinoma
line of therapy


Open-label, dose escalation, multi-center, Phase I / II study to assess the safety of an autologous T-cell product (ET140203) in adult subjects with Alpha-fetoprotein (AFP)-positive/Human Leukocyte Antigen (HLA) A-2-positive advanced hepatocellular carcinoma (HCC).


The purpose of this study is to investigate an autologous T-cell therapy for advanced hepatocellular carcinoma (HCC). ET140203 T cells are autologous T cells genetically modified to carry a TCR-mimic (TCRm) construct capable of mediating cell killing by targeting tumor specific intracellular antigens and addressing solid tumor therapy challenges.

Condition Hepatocellular Carcinoma, Liver Cancer, Liver Neoplasm, Metastatic Liver Cancer
Treatment ET140203 autologous T cell product
Clinical Study IdentifierNCT04502082
SponsorEureka Therapeutics Inc.
Last Modified on21 September 2023

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