Open-label, dose escalation, multi-center, Phase I / II study to assess the safety of an autologous T-cell product (ET140203) in adult subjects with Alpha-fetoprotein (AFP)-positive/Human Leukocyte Antigen (HLA) A-2-positive advanced hepatocellular carcinoma (HCC).
The purpose of this study is to investigate an autologous T-cell therapy for advanced hepatocellular carcinoma (HCC). ET140203 T cells are autologous T cells genetically modified to carry a TCR-mimic (TCRm) construct capable of mediating cell killing by targeting tumor specific intracellular antigens and addressing solid tumor therapy challenges.
| Condition | Hepatocellular Carcinoma, Liver Cancer, Liver Neoplasm, Metastatic Liver Cancer |
|---|---|
| Treatment | ET140203 autologous T cell product |
| Clinical Study Identifier | NCT04502082 |
| Sponsor | Eureka Therapeutics Inc. |
| Last Modified on | 21 September 2023 |
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