A Pilot Study of Empagliflozin in the Treatment of Acromegalic Cardiomyopathy

  • STATUS
    Recruiting
  • days left to enroll
    24
  • participants needed
    10
  • sponsor
    Huashan Hospital
Updated on 25 January 2021
insulin
heart failure
pituitary
somatostatin
growth hormone
adenoma
insulin-like growth factor
growth factor
cardiomyopathy

Summary

Acromegaly is a disease characterized by excess growth hormone(GH) and insulin like growth factor(IGF)-1. Pituitary GH secreting adenoma is the major cause of acromegaly. Acromegalic cardiomyopathy is one of the leading causes of death in acromegalic patients. No efficient medicine is available for acromegalic cardiomyopathy until now and there were limited studies. Empagliflozin is proved to decrease the risk of heart failure in diabetic patients and independent of blood glucose control. We planed to evaluate the structure of heart by MRI before and after 6 months treatment with empagliflozin in acromegalic patients to investigate the effect of empagliflozin on acromegalic cardiomyopathy.

Details
Condition Acromegaly, Acromegaly, Heart disease, Heart disease, Cardiac Disease, Cardiomyopathy, Cardiomyopathy, Cardiac Disease, cardiomyopathies, myocardial diseases
Treatment Empagliflozin
Clinical Study IdentifierNCT04520646
SponsorHuashan Hospital
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients with pituitary GH adenomas confirmed by surgery
active acromegalic patients although treated with surgery,radiation therapy
and somatostatin analogs

Exclusion Criteria

patients with contraindications to empagliflozin pregnant patients patients with poor control of hypertension(SBP>150mmHg or DBP>95mmHg patients with contraindications to MRI
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