A Multicenter Clinical Trial: Efficacy Safety of Fecal Microbiota Transplantation for Inflammatory Bowel Disease

  • STATUS
    Recruiting
  • End date
    Apr 24, 2024
  • participants needed
    200
  • sponsor
    Zhongshan Hospital Xiamen University
Updated on 24 January 2021
remission
microbiota
inflammatory bowel disease
crohn's disease
fecal microbiota transplantation
intestinal diseases

Summary

There are many limitations in the current treatments of Inflammatory bowel disease(IBD). Some patients have no or little reaction to the traditional drugs. Now the investigators realized that the intestinal microbiota is closely associated with the development of IBD. In recent years, a retrospective study showed that the overall efficiency of fecal microbiota transplantation (FMT) for IBD was 79%, the overall remission rate was 43%, which opened a new chapter in the treatment of IBD. So the standardized fecal microbiota transplantation is considered to be simple but effective emerging therapies for the treatment of IBD. In this project the investigators intend to carry out a single-center, randomized, single-blind clinical intervention study. The investigators plan to recruit patients with IBD (Ulcerative Colitis and Crohn's Disease) in China. The patients will be randomly divided into two groups, one group will be given treatment of standardized fecal microbiota transplantation, the other will be simply treated with traditional drugs, followed up for at least 1 year. The investigators aim to determine the efficiency, durability and safety of Fecal Microbiota Transplantation for IBD treatment, and further to explore which major microbiota may effect in this project.

Description

In this projects the investigators aim to re-establish a gut balance of intestinal microbiota through Standardized Fecal Microbiota Transplantation for IBD (UC and CD). We have established a standardized isolation, store, and transport steps of fecal bacteria from donated fresh stool in the laboratory. Then the bacteria will be transplanted to mid-gut by capsule. Patients in this study will be assigned to receive standardized FMT three times or not and would be followed up for at least 1 year. The clinical symptoms, sign, blood tests, endoscopy and questionnaire will be used to assess the efficiency, durability and safety of Standardized FMT at the start and end of the projects. At last, we will use 16S-rDNA to estimate the change of intestinal microbiota.

Details
Condition Inflammatory Bowel Disease, Ulcerative Colitis Type, Inflammatory Bowel Disease, Ulcerative Colitis Type, Inflammatory Bowel Disease, Ulcerative Colitis Type
Treatment Fecal Microbiota Capsule
Clinical Study IdentifierNCT04521205
SponsorZhongshan Hospital Xiamen University
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Standard or conventional medicine treatment ineffective of IBD patients
IBD patients with recurrent symptoms
IBD patients who had drug dependence or recurrence when reduced or discontinued use
Untreated IBD patients who voluntarily received FMT

Exclusion Criteria

IBD patients with contraindications for gastrointestinal endoscopy
IBD patients combined with other serious diseases such as respiratory failure, heart failure and severe immunodeficiency
IBD patients with indication of surgery
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