Influence of Radiotherapy and Chemotherapy in the Value of Peripheral Blood Lymphocyte Subsets Among Thoracic Cancer

  • End date
    Dec 24, 2026
  • participants needed
  • sponsor
    Shanghai Cancer Hospital, China
Updated on 24 January 2021
platelet count
renal function
direct bilirubin
squamous cell carcinoma
lung cancer
neutrophil count
chemotherapy regimen
cancer chemotherapy
esophagus cancer
kidney function test
lung carcinoma


This study is an observation, single center study to evaluate the alternations and prognostic value of peripheral blood lymphocyte (PBL) in patients diagnosed with thoracic cancers, including lung cancer, esophageal squamous cell carcinoma and thymic epithelial carcinoma underwent radiotherapy with or without chemotherapy.

Condition Non-Small Cell Lung Cancer, Esophageal Cancer, Esophageal Cancer, Squamous cell carcinoma, Squamous cell carcinoma, Esophageal Squamous Cell Carcinoma, Thymic Epithelial Tumor, Squamous Cell Carcinoma of Esophagus, nsclc
Clinical Study IdentifierNCT04522687
SponsorShanghai Cancer Hospital, China
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Age at least 18 years. ECOG PS 0-1. Pathologically confirmed NSCLC, esophageal
squamous cell carcinoma or thymic epithelial tumor
Life expectancy of more than 3 months. Patients with no indications for
palliative radiotherapy in the opinion of the investigator
Patients with a prior history of surgery are eligible if they have recovered
adequately from the toxicity and/or complications of surgery
Signed informed consent for the use of fresh tumor biopsies before and during
the treatment
Women of childbearing age and men must agree to use effective contraception
during the trial
Adequate organ function within 1 week prior to the enrollment
Adequate bone marrow function: hemoglobin 80g/L, white blood cell (WBC) count 4.0 10 ^ 9/L or neutrophil count 1.5 10 ^ 9/L, and platelet count 100 10 ^ 9/L
Adequate hepatic function: total bilirubin < 1.5 x upper limit of normal (ULN). Note: If total bilirubin is > 1.5 x ULN, direct bilirubin must ULN, Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) 2.5 ULN
Adequate renal function: serum creatinine 1.5 x ULN or creatinine clearance 50 mL/min

Exclusion Criteria

Pregnant or lactating women. History of any other malignancy. Patients in whom
palliative radiotherapy is indicated in the opinion of the investigator
Active infection, congestive heart failure, myocardial infarction within the 6
months prior to enrollment, unstable angina pectoris or cardiac arrhythmia
Patients who have received tumor vaccine; or administration of live
attenuated vaccine within 4 weeks before the start of treatment
Mental disorders, drug abuse, and social condition that may negatively impact
compliance in the opinion of the investigator
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