PPMI: A New Horizon for Parkinson's Research

  • End date
    Dec 20, 2033
  • participants needed
  • sponsor
    The Michael J. Fox Foundation for Parkinson's Research
Updated on 15 June 2021
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The Parkinson’s Progression Markers Initiative (PPMI) seeks to uncover insights into Parkinson’s disease (PD) onset and progression that could transform how we diagnose, treat, and potentially prevent (PD). PPMI has already contributed to new understanding around disease biology and experience, and its findings and design have led to more efficient clinical research.
Now PPMI is looking to bring together a larger and more diverse group of individuals – both with and without PD – who can help contribute to a more detailed look into the way the disease develops and changes over time. These key insights could help lead to critical advancements across the spectrum of care: from the earlier identification of people who may be at risk for developing PD to innovative new treatments that could improve quality of life and slow disease progression.


PPMI is an observational research study, which means participants will be monitored and evaluated but will not receive study-related treatment or medication as part of participation. We are asking volunteers to enroll for at least five years so that the study team can gather information on PD development and progression, as well as natural aging. Participants may be asked to continue beyond five years based on the status of the study.

Condition Parkinson's disease, *Healthy Volunteers
Clinical Study IdentifierNCT04477785
SponsorThe Michael J. Fox Foundation for Parkinson's Research
Last Modified on15 June 2021


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Inclusion Criteria

Have you been diagnosed with Parkinson's disease within the last 2 years and not currently taking standard PD medications? Or
Do you have a first-degree biologic family member (for example, a parent, child, or sibling) with Parkinson's disease? Or
Do you have a known genetic mutation, loss of smell, or history of physically acting out dreams during your sleep? Or
Are you a person who does not have Parkinson’s disease (or other known neurological disease) and is otherwise generally healthy?
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How to participate?

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What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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