Gene Expression Changes In Young and Geriatric Skin

  • days left to enroll
  • participants needed
  • sponsor
    Wright State University
Updated on 7 April 2022
Accepts healthy volunteers


This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.

Condition UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging
Treatment Insulin-Like Growth Factor 1, No Insulin-Lie Growth Factor 1
Clinical Study IdentifierNCT03932162
SponsorWright State University
Last Modified on7 April 2022


Yes No Not Sure

Inclusion Criteria

White skin (Fitzpatrick types I and II)
Age 21-30 or 65 and older
Able to comprehend procedures/risks

Exclusion Criteria

Known photosensitivity
Currently on photosensitizing medications
Diabetes Mellitus
History of abnormal scarring
History of skin infections
Known allergy to lidocaine local anesthetic
Pregnancy or nursing
Other serious health issues
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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