Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

  • STATUS
    Recruiting
  • End date
    Sep 1, 2025
  • participants needed
    1050
  • sponsor
    Johns Hopkins University
Updated on 4 October 2022
diabetes
angiography
retinopathy
diabetic retinopathy
glaucoma
optical coherence tomography
thyroid disease
eye disease
retinal vascular
macular degeneration
proliferative diabetic retinopathy
eye disorder
macular disease

Summary

This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.

Description

The objective of this study is to perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.

Subjects will be identified from healthy subjects (seen for screening eye exams) and diseased subjects undergoing standard-of-care treatment or screening at eye clinic locations. The study population will include subjects with retinal vascular disease including but not limited to diabetic retinopathy, hypertension, retinal vein/arterial occlusion, and macular degeneration. Subjects who are enrolled will undergo non-invasive, minimal risk, FDA approved diagnostic imaging procedures to identify vascular changes.

The study methods will include retrospective review and collection of clinically approved imaging data that is obtained through standard-of-care methods for subjects who meet inclusion and exclusion criteria. Subjects who are identified in this manner will be asked to participate in a prospective study by each clinical study site.

The study end-points include the correlation of diagnostic imaging findings from OCT based images with fundus photographs, clinical disease stage and visual acuity.

Details
Condition Retinal Vein Occlusion, Hypertension,Essential, Essential Hypertension, Vascular Diseases, Diabetic Retinopathy, Primary Hypertension, Venous Thrombosis, Retinal Vascular Disorder, Deep Vein Thrombosis, Diabetic Macular Edema
Treatment Swept-Source OCT Angiography, Spectral-Domain OCT Angiography, Fundus Imagning, Axial Length Measurement Device, Fundus Imaging
Clinical Study IdentifierNCT04505618
SponsorJohns Hopkins University
Last Modified on4 October 2022

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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