Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA

  • End date
    Mar 4, 2024
  • participants needed
  • sponsor
    Novartis Pharmaceuticals
Updated on 4 October 2022


This study will explore the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage. Efficacy will be evaluated in the context of the systemic safety and local tolerability of the investigational drug.


The purpose of this study is to evaluate the safety, tolerability and preliminary efficacy of multiple intra-articular injections of LRX712 in the knee when treating patients with knee osteoarthritis of mild/moderate severity, in order to support the further clinical development. This study will also allow refinement of the systemic and local pharmacokinetics of LRX712 and the exploration of drug effects on biomarkers of cartilage breakdown and regeneration in OA patients.

Condition Osteoarthritis (OA)
Treatment Placebo, LRX712
Clinical Study IdentifierNCT04097379
SponsorNovartis Pharmaceuticals
Last Modified on4 October 2022


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