Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 700
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- sponsor
- University of Aberdeen
Summary
Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.
Description
Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.
Details
| Condition | Takotsubo Syndrome |
|---|---|
| Treatment | Blood collection for genetic analysis |
| Clinical Study Identifier | NCT04513054 |
| Sponsor | University of Aberdeen |
| Last Modified on | 7 October 2021 |
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