Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    University of Aberdeen
Updated on 7 October 2021


Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.


Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Condition Takotsubo Syndrome
Treatment Blood collection for genetic analysis
Clinical Study IdentifierNCT04513054
SponsorUniversity of Aberdeen
Last Modified on7 October 2021


Yes No Not Sure

Inclusion Criteria

All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date
Familial cases elsewhere in the world who would be willing to participate

Exclusion Criteria

Unwillingness to participate
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