Understanding the Roles of Hormones in Adipocyte Remodeling Following Menopause

  • STATUS
    Recruiting
  • days left to enroll
    31
  • participants needed
    12
  • sponsor
    Pennington Biomedical Research Center
Updated on 14 February 2021
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Summary

The overarching aims of this study are to:

  1. Characterize the rate of in vivo adipogenesis, and changes in adipose tissue gene and protein expression, in the scABD and scFEM depots of women undergoing surgical menopause (E2, FSH).
  2. Characterize the rate of in vivo adipogenesis, and changes in adipose tissue gene and protein expression, in the scABD and scFEM depots of women undergoing gonadal suppression (E2, FSH).

Description

This is a cross-sectional study where two groups of premenopausal women (ages 18-50 y) will be enrolled in a parallel arm study:

  • Arm 1 (Surgical Menopause): up to 6 women undergoing laparoscopic, elective bilateral oophorectomy [Site: Pennington Biomedical Research Center].
  • Arm 2 (Pharmacology-Induced Menopause): up to 6 women undergoing gonadal suppression via leuprolide acetate (Lupron [AbbVie Inc.]) [Site: UC-Denver].

We will compare each arm of women to non-oophorectomized, premenopausal women (controls) with normal menstrual cycles (Apple&Pear study; NCT01748994; PI: Ravussin) selectively matched (1:2) for age and BMI. The Apple&Pear study uses the same in vivo adipogenesis labeling protocol, with similar age and BMI criteria, as the proposed study.

Details
Condition adiposity, Obesity, Estrogen Deficiency, Hormone Deficiency, Menopause Surgical, Follicle-Stimulating Hormone Deficiency, Follicle-Stimulating Hormone Deficiency, surgical menopause, Follicle-Stimulating Hormone Deficiency
Treatment 'Surgical Menopause' Group, 'Drug-Induced Menopause' Group
Clinical Study IdentifierNCT03856268
SponsorPennington Biomedical Research Center
Last Modified on14 February 2021

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