Influence of Stress and Psychiatric Symptoms on Children With Tourette Syndrome (InSPSCTS)

  • STATUS
    Recruiting
  • days left to enroll
    16
  • participants needed
    120
  • sponsor
    Vanderbilt University Medical Center
Updated on 10 May 2022
depression
anxiety
deficit
obsessive compulsive disorder
tics
attention deficit hyperactivity disorder
hyperactivity
attention deficit disorder

Summary

Investigators propose a cross-sectional, observational pilot study to examine the contribution of stress, family dynamics, and peer relationships to quality of life (QOL) in adolescents with Tourette syndrome (TS). Investigators will recruit two groups of participants: 1) adolescents aged 13-17 years of age with TS and 2) adolescents aged 13-17 without any neurologic or psychiatric diagnoses. Participants and one of their parents/caregivers will complete a series of questionnaires screening for and quantifying the extent of stress and mental health symptoms, including anxiety, depression, obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD). Participants will also complete instruments characterizing family interactions and peer relationships. Adolescents with TS will also undergo a semi-structured interview assessing the severity of their tics.

Description

Tourette syndrome (TS) is a multi-faceted neurodevelopmental disorder with wide-ranging impact on adolescent quality of life (QOL). Comorbid psychiatric and psychological factors exert greater influence on QOL than tics in TS, but the specific role of stress, family dynamics, and peer relationships has been largely overlooked, despite the fact that these factors are known to impact QOL in those with chronic disease. Investigators propose a cross-sectional, observational pilot study to examine the contribution of stress, family dynamics, and peer relationships to QOL in adolescents with TS. The primary goal of this study is to collect sufficient data for hypothesis-generation and power analysis refinement in planning of a larger scale study.

Investigators will recruit adolescents aged 13-17 years of age with TS presenting for regular care at the Vanderbilt Pediatric Neurology Clinic. Adolescents without any neurologic or psychiatric diagnoses will be recruited as a control population. Participants and one of their parents/caregivers will complete a series of questionnaires screening for and quantifying the extent of stress and mental health symptoms, including anxiety, depression, obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD). Participants will also complete instruments characterizing family interactions and peer relationships. The scale battery can be completed by the adolescent and caregiver in parallel and is anticipated to take 60-75 minutes total to complete. Adolescents with TS will also undergo a semi-structured interview assessing the severity of their tics. The study plans to enroll subjects over a 12-month time frame.

Details
Condition Tourette Syndrome in Adolescence, Tourette Syndrome, Tourette Syndrome in Children
Clinical Study IdentifierNCT04449003
SponsorVanderbilt University Medical Center
Last Modified on10 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

adolescent age 13-17 years of age
adolescent diagnosis of Tourette syndrome (TS)
English-speaking adolescent and caregiver (as validated questionnaires are in English)
adolescent and caregiver willingness and ability to complete relevant questionnaires

Exclusion Criteria

cognitive or attentional impairment precluding ability of adolescent or caregiver to complete self-report questionnaires
adolescent diagnosis of genetic conditions besides TS and its known comorbidities
adolescent with severe medical conditions unrelated to TS (e.g. uncontrolled seizures, prominent heart conditions)
Inclusion Criteria for adolescents without any neurologic or psychiatric
diagnoses
adolescent age 13-17 years of age
no prior neurologic or psychiatric diagnoses
English-speaking adolescent and caregiver
adolescent and caregiver willingness and ability to complete relevant questionnaires
Exclusion Criteria for adolescents without any neurologic or psychiatric
diagnoses
cognitive or attentional impairment precluding ability of adolescent or caregiver to complete self-report questionnaires
adolescent with severe medical conditions
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