Memory Enhancement by Gamma-hydroxybutyrate vs. Trazodone in Major Depressive Disorder.

  • End date
    Dec 31, 2021
  • participants needed
  • sponsor
    Erich Seifritz
Updated on 25 January 2021
major depressive disorder


30 healthy adults and 30 patients with major depressive disorder, will take part in three single-application pharmacological interventions (GHB vs. Trazodone vs. placebo p.o.) to test potential effects of these drugs on nocturnal memory consolidation. All participants will be assessed with mood state questionnaires, tests of emotional, procedural and declarative memory consolidation, polysomnography, EEG and neuroinflammatory biomarkers. At experimental nights, learning tasks are performed prior to sleep. The next morning, recalling tasks are performed. Each subject will pass through 5 study nights (1 screening, 1 adaptation and 3 experimental nights).

Condition Major depression, Endogenous depression, major depressive disorder, major depressive disorders
Treatment placebos, Trazodone, GHB, GHB
Clinical Study IdentifierNCT04082806
SponsorErich Seifritz
Last Modified on25 January 2021


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