4 Repeat Tauopathy Neuroimaging Initiative (4RTNI)

  • STATUS
    Recruiting
  • days left to enroll
    79
  • participants needed
    110
  • sponsor
    University of California, San Francisco
Updated on 26 January 2022
brain imaging
progressive supranuclear palsy
tauopathies
corticobasal degeneration

Summary

The purpose of this study is to evaluate several different tests, including brain imaging, eye movement testing, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future. Recent advances in our understanding of the biological causes of these diseases offer hope for new treatments. As such treatments are developed, sensitive and specific biological measurements (biomarkers) will be needed to provide precise and direct measures of the state of the brain, which will improve the statistical power of clinical trials. Brain imaging with Magnetic Resonance Imaging (MRI) has previously been used to measure disease-related changes in the brain. The goal of this study is to identify the best methods of analysis (including eye movements, imaging, and behavioral measures) for tracking PSP and CBD over time. In addition, certain biomarkers in the blood and cerebrospinal fluid might also be useful for following these diseases over time. This study will examine the value of blood and CSF biomarkers relative to brain imaging and functional measures.

Details
Condition Progressive Supranuclear Palsy, Corticobasal Degeneration
Treatment Observational study
Clinical Study IdentifierNCT01804452
SponsorUniversity of California, San Francisco
Last Modified on26 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of Progressive Supranuclear Palsy or Corticobasal Degeneration
Must have a reliable study partner who has frequent contact with the subject
Willing and able to undergo testing procedures

Exclusion Criteria

Significant neurological disease other than PSP or CBD
Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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