4 Repeat Tauopathy Neuroimaging Initiative (4RTNI)

  • STATUS
    Recruiting
  • participants needed
    110
  • sponsor
    University of California, San Francisco
Updated on 9 December 2022
brain imaging
progressive supranuclear palsy
tauopathies
corticobasal degeneration

Summary

The purpose of this study is to evaluate several different tests, including brain imaging, eye movement testing, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future. Recent advances in our understanding of the biological causes of these diseases offer hope for new treatments. As such treatments are developed, sensitive and specific biological measurements (biomarkers) will be needed to provide precise and direct measures of the state of the brain, which will improve the statistical power of clinical trials. Brain imaging with Magnetic Resonance Imaging (MRI) has previously been used to measure disease-related changes in the brain. The goal of this study is to identify the best methods of analysis (including eye movements, imaging, and behavioral measures) for tracking PSP and CBD over time. In addition, certain biomarkers in the blood and cerebrospinal fluid might also be useful for following these diseases over time. This study will examine the value of blood and CSF biomarkers relative to brain imaging and functional measures.

Details
Condition Progressive Supranuclear Palsy, Corticobasal Degeneration
Treatment Observational study
Clinical Study IdentifierNCT01804452
SponsorUniversity of California, San Francisco
Last Modified on9 December 2022

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