Azacitidine and Homoharringtonine in JMML

  • End date
    Jan 1, 2025
  • participants needed
  • sponsor
    Air Force Military Medical University, China
Updated on 25 January 2021
myeloid leukemia
refractory acute myeloid leukemia (aml)


Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. Azacitidine and homoharringtonine, which exhibited a anticancer mechanism and has been widely used in patients with relapse/refractory acute myeloid leukemia (AML). However, the efficacy of these agents has not been elucidated in children with JMML. The primary objective is to assess the treatment effect on response rate in this subject population.

Condition Juvenile Myelomonocytic Leukemia
Treatment Azacitidine and homoharringtonine
Clinical Study IdentifierNCT04505995
SponsorAir Force Military Medical University, China
Last Modified on25 January 2021


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