Characterizing Disease Biology, Treatment and Toxicity in Older Adults With Hepatocellular Carcinoma

  • STATUS
    Recruiting
  • End date
    Jan 1, 2025
  • participants needed
    84
  • sponsor
    The University of Texas Health Science Center at San Antonio
Updated on 24 December 2021
cancer

Summary

This is an observational, prospective cohort study that will recruit a diverse sample of 84 participants with newly diagnosed with unresectable, advanced hepatocellular carcinoma (HCC) at the UT Health Cancer Center in San Antonio. This study uses geriatric assessment tools with participants 65 years and older and collects adverse events and exploratory markers of aging for all participants.

Description

The results from this study will allow us to identify unique disease characteristics of older participants and to study treatment patterns that may be barriers to treatment and risk factors for increased morbidity. Characteristics of Comprehensive Geriatric Assessment will be obtained prior to standard interventional treatment for participants that are 65 years or older. Observations will be made of treatment toxicities and cellular senescence with treatment outcomes. Findings from this study will result in the development of R01 intervention studies that develop and validate a treatment algorithm based on these associations to provide older adults with a personalized treatment plan.

Details
Condition Carcinoma, Hepatocellular
Treatment comprehensive geriatric assessment (CGA)
Clinical Study IdentifierNCT03894917
SponsorThe University of Texas Health Science Center at San Antonio
Last Modified on24 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Histologically or radiographically (CT or MRI) confirmed newly diagnosed hepatocellular carcinoma
Age 18 years and older
Patients with advanced, unresectable HCC as determined by the treating physician

Exclusion Criteria

Patients with resectable HCC who are still candidates for locoregional therapy
Patients receiving prior systemic or locoregional therapy
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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