Pancreatic Endotherapy for Refractory Chronic Pancreatitis (PERCePT)
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- STATUS
- Recruiting
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- End date
- Jul 10, 2025
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- participants needed
- 30
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- sponsor
- Oregon Health and Science University
Summary
The purpose of this study is to evaluate whether endoscopic ultrasound (EUS) only versus EUS + endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic endotherapy reduces pain in the treatment of chronic pancreatitis with pancreatic duct obstruction.
Description
This is a single center, pilot, sham-controlled clinical trial of ERCP with pancreatic endotherapy for pain secondary to chronic calcific pancreatitis with main pancreatic duct obstruction. Potential subjects will undergo a comprehensive baseline assessment including Quantitative Sensory Testing, to ensure enrollment criteria are met and baseline covariates are measured. Eligible subjects will complete a 14-day run-in period. If eligibility criteria persist, subjects will be randomized to diagnostic endoscopic ultrasound (EUS) + sham pancreatic endotherapy or diagnostic EUS + ERCP with pancreatic endotherapy as defined in the study protocol. Subjects will be followed by a blinded physician for the next 90 days, at which time the pilot trial outcomes will be measured. Regardless of outcomes, all subjects will be followed longitudinally for 12 months after randomization.
Details
| Condition | Pancreatic Duct Stone, Pancreatic Duct Stricture, Pancreatic Duct Dilatation |
|---|---|
| Treatment | EUS + SHAM, EUS + Pancreatic Endotherapy |
| Clinical Study Identifier | NCT04232670 |
| Sponsor | Oregon Health and Science University |
| Last Modified on | 4 October 2022 |
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