Nanoparticle albumin-bound paclitaxel has greater efficacy and favorable safety profile than standard paclitaxel. However, rate of neuropathy caused by nanoparticle albumin-bound paclitaxel is higher than standard paclitaxel, and is one of its dose-limited toxicities. Previously, compression therapy by surgical gloves has shown effectiveness in preventing chemotherapy-induced neuropathy. We designed this multi-center prospective self-control phase III study to investigate the efficacy of compression gloves to reduce albumin-binding paclitaxel induced sensory and motor neurotoxicity of upper extremities.
| Condition | Peripheral Neuropathy, Peripheral Neuropathy, peripheral nerve disease, peripheral nerve damage |
|---|---|
| Treatment | Compression gloves |
| Clinical Study Identifier | NCT04446819 |
| Sponsor | Fudan University |
| Last Modified on | 28 June 2022 |
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