Compression Gloves to Reduce Albumin-binding Paclitaxel Induced Peripheral Sensory and Motor Neurotoxicity (REMAINING)

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  • sponsor
    Fudan University
Updated on 28 June 2022


Nanoparticle albumin-bound paclitaxel has greater efficacy and favorable safety profile than standard paclitaxel. However, rate of neuropathy caused by nanoparticle albumin-bound paclitaxel is higher than standard paclitaxel, and is one of its dose-limited toxicities. Previously, compression therapy by surgical gloves has shown effectiveness in preventing chemotherapy-induced neuropathy. We designed this multi-center prospective self-control phase III study to investigate the efficacy of compression gloves to reduce albumin-binding paclitaxel induced sensory and motor neurotoxicity of upper extremities.

Condition Peripheral Neuropathy, Peripheral Neuropathy, peripheral nerve disease, peripheral nerve damage
Treatment Compression gloves
Clinical Study IdentifierNCT04446819
SponsorFudan University
Last Modified on28 June 2022

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