The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly

  • End date
    Jun 1, 2024
  • participants needed
  • sponsor
    Shenzhen Second People's Hospital
Updated on 14 May 2022
Accepts healthy volunteers


Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.

Condition PND
Treatment Spinal anesthesia, nerve block combined with general anesthesia
Clinical Study IdentifierNCT04488952
SponsorShenzhen Second People's Hospital
Last Modified on14 May 2022


Yes No Not Sure

Inclusion Criteria

aged 60-85years
Received elective surgery of unilateral lower extremity orthopedics
The anesthesia lasted more than 2 hours

Exclusion Criteria

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