Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

  • STATUS
    Recruiting
  • End date
    Feb 23, 2024
  • participants needed
    726
  • sponsor
    University Hospital, Strasbourg, France
Updated on 4 October 2022
mediators
Accepts healthy volunteers

Summary

The light has visual and non-visual effects on organism and can act on the behavior, the mood, the cognition and the sleep. These effects are mediated by "classical" retina photoreceptors which allow vision (rods, cones) but also melanopsin cells. The non-visual effects of light seems to be altered in many neurological, psychiatric or ophtalmological conditions but their exact role in the pathogenesis remains poorly understand. The purpose of the study is to increase our knowledge of the non-visual effects of light and establish new therapeutic applications

Details
Condition Sleep Disorders, Neurological Pathologies, Psychiatric Pathologies, Ophthalmological Pathologies
Treatment Specific light exposures
Clinical Study IdentifierNCT03811964
SponsorUniversity Hospital, Strasbourg, France
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Man or woman
Aged 18 years or older
Subject having signed a free and informed consent
Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject

Exclusion Criteria

Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa
macular involvement of diabetes)
Cataract with significant vision loss <5/10
Chorioretinal neovascularization
Subject in exclusion period determined by previous or current study
Impossibility to give the subject information enlightened (subject in emergency
Subject under the protection of justice
situation, difficulties of understanding the subject, ...)
Subject under guardianship or curatorship
Pregnancy / Breastfeeding
Clear my responses

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