Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

STATUS

Recruiting
End date

Feb 23, 2024
participants needed

726
sponsor

University Hospital, Strasbourg, France

Updated on 4 October 2022

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Accepts healthy volunteers

Summary

The light has visual and non-visual effects on organism and can act on the behavior, the mood, the cognition and the sleep. These effects are mediated by "classical" retina photoreceptors which allow vision (rods, cones) but also melanopsin cells. The non-visual effects of light seems to be altered in many neurological, psychiatric or ophtalmological conditions but their exact role in the pathogenesis remains poorly understand. The purpose of the study is to increase our knowledge of the non-visual effects of light and establish new therapeutic applications

Details

Condition	Sleep Disorders, Neurological Pathologies, Psychiatric Pathologies, Ophthalmological Pathologies
Treatment	Specific light exposures
Clinical Study Identifier	NCT03811964
Sponsor	University Hospital, Strasbourg, France
Last Modified on	4 October 2022

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Man or woman
	Aged 18 years or older
	Subject having signed a free and informed consent
	Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject
Exclusion Criteria
	Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa
	macular involvement of diabetes)
	Cataract with significant vision loss <5/10
	Chorioretinal neovascularization
	Subject in exclusion period determined by previous or current study
	Impossibility to give the subject information enlightened (subject in emergency
	Subject under the protection of justice
	situation, difficulties of understanding the subject, ...)
	Subject under guardianship or curatorship
	Pregnancy / Breastfeeding

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Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies