Neurobiological Markers of Major Depression in Individuals with Grief.

    Not Recruiting
Updated on 24 January 2022


This study is looking for people over 40 who are grieving the death of a loved one (for example, a partner, sibling, or child), and may or may not be depressed. The study is also looking for healthy people who have not recently experienced a death, as a comparison. The study is intended to identify some of the brain changes associated with depression during grief.


Study schedule
Study-start activities (to be completed over two sessions):
-You will answer questions about yourself and your health.
-You will have a medical / neurological exam.
-You will have assessments of your grief, mood, memory, cognition, and behavior.
-You will give a blood sample. You must fast overnight before the blood sample.
-You will have a brain scan (described below).
The study may end at this point for some participants. Or, based on the results of the study-start activities, some participants may go on to do the activities below:
-You will repeat the memory and cognitive assessments.
-You will repeat the brain scan (described below).
The study will end after about 26 weeks.

Study activities may include
-Answering questions about yourself and your health.
-Having a medical / neurological exam.
-Having assessments of your grief, mood, memory, cognition, and behavior in the form of interview-style conversations, paper-and-pencil questionnaires, computer tests, and/or other activities.
-Fasting overnight before the blood sample is taken.
-Having a sample of blood taken from your arm vein using a needle.
-Having a brain scan (described below).

Treatment or experiment details:
-The brain scan is an MRI. For this, you’ll lie inside the scanning machine for about 1 hour while it takes a 3-D image of your brain.
-There is no treatment being tested in this study.

Additional details:
-You will be compensated for your time and travel expenses.

Condition *Healthy Volunteers
Clinical Study IdentifierTX249209
Last Modified on24 January 2022

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