Using Connectomics to Characterize Risk for Alzheimer's Disease

Updated on 24 January 2022
cognitive impairment
mild cognitive impairment
Accepts healthy volunteers


This study is looking for people over the age of 45 who have Alzheimer’s, mild cognitive impairment, or memory problems. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain scans may change over time.


Study schedule:
-You will have 4 or 5 study visits. Each visit will take 1-3 hours.
At the start of the study:
-You will give a sample of blood.
-You will do cognitive testing.
-You will have brain scans (described below).
At the end of the study:
-You will repeat some or all of the study-start activities.
The study will take about a year.

Study activities may include:
-Having a sample of blood taken from your arm vein, using a needle.
-Doing cognitive testing, which may be in the form of interview-style conversations, paper-and pencil questionnaires, computer tests, and/or other activities.
-Doing brain scans (described below).
-Having an injection as a standard part of the brain scan procedure.

Treatment or experiment details:
-One of the brain scans is an MRI. For this, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-The other brain scan is a PET scan. For this, you will have an injection in your arm vein. Then, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-The study is interested in the way that connections in the brain change over time in people with Alzheimer’s vs. during healthy aging.
-There is no treatment or experiment being tested in this study.

Condition Dementia, Dementia, Alzheimer's Disease, Alzheimer's Disease, Mild Cognitive Impairment, Memory Problems, *Healthy Volunteers
Clinical Study IdentifierTX249207
Last Modified on24 January 2022


Yes No Not Sure

Inclusion Criteria

You could be eligible for this study if
You are between the ages of 45 and 85
You have a ‘study partner’—a family member, friend, or caregiver—who would be willing to accompany you on all study visits
You either
Have Alzheimer’s, mild cognitive impairment, or memory loss; or
Are cognitively normal
You may not be eligible for this study if
You cannot have an MRI scan, for example because of metal in your body
You are currently taking an experimental medication
You are undergoing chemotherapy
You are pregnant
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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