Effect of Aerobic Exercises on Sex Hormones and Coagulation Factors in Postmenopausal Elderly Women

  • STATUS
    Recruiting
  • End date
    Aug 20, 2022
  • participants needed
    40
  • sponsor
    Cairo University
Updated on 18 August 2021
thrombosis
hemostatic
fibrinogen
fibrinolysis
coagulation factor

Summary

PURPOSE

to determine the effect of aerobic exercise training on sex hormones and coagulation factors in postmenopausal elderly women

BACKGROUND

Cardiovascular disease (CVD) is the largest cause of death in women, and the risk of developing CVD increases after menopause . Because thrombosis is thought to be a cause of most acute cardiovascular events, abnormalities in endogenous coagulation and fibrinolysis may play an important role in the risk of an acute cardiovascular event. Aging is also associated with adverse changes in both coagulation and fibrinolysis. For instance, postmenopausal women exhibit higher fibrinogen levels and lower levels of endogenous fibrinolysis. Physical activity and physical fitness have consistently been linked to lower CVD rates in women. In fact, an inverse association between physical activity and total mortality, as well as a 50% reduction in risk of myocardial infarction, has been observed in physically active postmenopausal women. In addition to the numerous other benefits provided by regular physical activity, one of the mechanisms mediating the cardioprotective effect may be changes in the hemostatic system, particularly fibrinolysis

HYPOTHESES

Aerobic exercises may have no effect on sex hormones and coagulation factors in elderly postmenopausal women

RESEARCH QUESTION:

Do aerobic exercises effect on sex hormones and coagulation factors in elderly postmenopausal women in response to exercises?

Description

It is an interventional study in which 40 women estimated to enroll according to random allocation and assigned into two groups equally. The study group will receive aerobic exercises in addition to diet recommendations while the control group will receive diet recommendations. the aerobic exercises time of session 40-50 min initial 10 min warm up exercises on treadmill in low intensity and active phase 20- 30 min intensity will increase until patient reach to target heart rate then intensity decrease until session will be ended by cooling down phase for 10 min . The volunteers will perform exercises 3 times per week for 12 weeks .coagulation factors(Prothrombin time, Partial Thromboplastin Time , plasminogen activator inhibitor-1 , fibrinogen and tissue plasminogen activator )will be measured and sex hormones (estradiol ,testosterone. sex hormone binding globin ) pre and post intervention

Details
Condition Coagulopathy, clotting, bleeding diathesis, bleeding tendency, blood coagulation disorders, coagulopathies, bleeding disorders, coagulation disorder, bleeding disorder, clotting disorders, blood clotting disorders
Treatment Diet Recommendations, aerobic exercises in addition to diet recommendations
Clinical Study IdentifierNCT04488341
SponsorCairo University
Last Modified on18 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

forty Postmenopausal women (60-70 y)
Body mass index (BMI) ranged from 35 to 39.9 kg/m2

Exclusion Criteria

regular medications(e.g., -blockers, -blockers, digoxin, diuretics, aspirin, nitrates, Presently using hormone replacement therapy (HRT) and non steroidal anti-inflammatory drugs
smoking
cognitive impairment that will make it difficult to partake in the study
presence of malignant disease
blood donation within the last 6 months
Participation as a subject in any type of study or research during the prior 90 days
hypertension
having active chronic illness (e.g., rheumatoid arthritis, hyperthyroidism, and inflammatory bowel disease) and diabetes mellitus or other (unstable) endocrine-related diseases
personal history of cardiovascular diseases
Orthopedic problems inhibiting exercises
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