Memory Research Study

Updated on 26 January 2022
Accepts healthy volunteers


This study is looking for people aged 60-90 who have mild cognitive impairment. The study is also looking for people with normal cognition, as a comparison. The study is testing a medical device to determine whether brain stimulation improves memory.


Study schedule:
There will be 8 days of study visits.
-The visits on Days 1, 2, and 7 will take 1.5-2 hours.
-The visits on Days 3, 4, 5, 6, and 8 will take a maximum of 1 hour.
During the study visits, you will have memory assessments, brain scans, and brain stimulation.

Study activities may include:
-Doing memory assessments in the form of interview-style conversations, paper-and pencil questionnaires, computer tests, or other activities.
-Having brain scans (described below).
-Having the assigned brain stimulation (described below).

Treatment or experiment details:
-The brain scan is an MRI. For this, you will lie inside the scanning machine for about an hour while it takes a 3-D image of your brain.
-The brain stimulation is transcranial magnetic stimulation (TMS). For this, a coil of wire inside a plastic casing will be placed against the surface of your scalp. Electricity will be passed through the coil in short pulses, creating magnetic fields. The magnetic fields will stimulate areas of the brain. Each session takes about 1 hour.
-The effect of TMS will be compared with the effect of placebo treatment. For placebo treatment, there will be pretend sessions that look and sound the same as active TMS, but no electricity will be passed through the coil.
-During the study, you will be assigned to have either:
Active TMS; or
Placebo TMS.
This will be determined randomly before the study starts, similar to flipping a coin.
-You will not know whether you are getting the active TMS or placebo TMS until after the study is over.

Additional details:
-Participants will receive $160. Participants can also have a picture of their brain and results of the study once it is completed.

Condition Mild Cognitive Impairment, *Healthy Volunteers
Clinical Study IdentifierTX249128
Last Modified on26 January 2022


Yes No Not Sure

Inclusion Criteria

You could be eligible for this study if
You are between 60 and 90
You are right-handed
You are fluent in English
You either
Have mild cognitive impairment; or
Have normal cognition
You may not be eligible for this study if
You have, or have had, a significant neurological or psychiatric condition including history of brain damage or dependence on drugs or alcohol
You cannot have an MRI scan, for example because of metal in your body
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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