Determining correlation of altered heart rate regulation and reduced glymphatic clearance in Alzheimer disease

Updated on 24 March 2022


This study is looking for people who have early Alzheimer’s. The study is interested in the relationship between heart health and brain health in Alzheimer’s.


Study schedule:
-There will be three study visits.

Study activities may include:
-Answering questionnaires about your health history.
-Having a brain scan (described below).
-Having an exercise test (described below).

Treatment or experiment details:
-The brain scan is an MRI. For this, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-The exercise test is cardiopulmonary stress testing. This is also called a stress test. For this, heartbeat sensors will be placed on your skin, and you will breathe through a mask/ mouthpiece to measure your oxygen use. Then, you will walk on a treadmill. The exercise intensity will be increased to test your body’s response to exercise.
-There is no treatment being tested in this study.
-The study is interested in the relationship between heart health and brain health in early Alzheimer’s.

Condition Alzheimer's Disease, Early Alzheimer's Disease
Clinical Study IdentifierTX249108
Last Modified on24 March 2022


Yes No Not Sure

Inclusion Criteria

You could be eligible for this study if
You are between the ages of 55 and 80
You are in good general health
You have early or mild Alzheimer’s
You may not be eligible for this study if
You have a significant medical condition, such as heart disease
You take medications for Alzheimer’s, or medications that could affect your heart function
For medical reasons, you cannot do exercise testing, or have failed an exercise test in the past due to heart problems
You cannot have an MRI, for example because of metal in your body
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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