Alzheimer’s Disease Research Center (ADRC) Longitudinal Study

  • STATUS
    Recruiting
Updated on 15 September 2020
cognitive impairment
dementia
mild cognitive impairment

Summary

This study is looking for people with mild cognitive impairment, young-onset Alzheimer’s, frontotemporal dementia, or Lewy body dementia. The study is also looking for cognitively-normal people over the age of 65, as a comparison. The study will follow the progression of various dementias to help with early detection, accurate diagnosis, and options for targeted treatments.

Description

Study schedule:
At the start of the study, you will have two study visits. Each visit will take 4-6 hours.
-You will do cognitive testing.
-You will answer questions about your mood, sleep, and habits.
-You will have a medical exam.
-You will give a blood sample.
-You will give a spinal fluid sample.
-You will have a brain scan (described below).

During the study, you will visit the study center once per year. Some or all of the study-start activities will be repeated.
The study will continue for the rest of your life.
After your death, your brain will examined under a microscope.

Study activities may include:
-Doing cognitive testing and answering questions about your mood, sleep, and habits, which may be in the form of interview-style conversations, paper-and-pencil questionnaires, computer tests, and/or other activities.
-Having a medical exam.
-Having a sample of blood taken from your arm vein, using a needle.
-Having a sample of spinal fluid taken from your lower back (spine), using a needle. This is also known as a lumbar puncture or spinal tap.
-Having a brain scan (described below).
-Donating your brain to science after your death.

Treatment or experiment details:
-The brain scan is an MRI. For this, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-Brain donation involves having an autopsy after death.
-There is no treatment or experiment being tested in this study.

Additional details:
-As a participant in this study, you will receive yearly feedback about your cognitive testing and your overall health. You will also have access to a social worker, quality of life programs, and education events. You will also have the opportunity to learn about other related research studies.

Details
Condition Frontotemporal Dementia, Alzheimer's Disease, Mild Cognitive Impairment, *Healthy Volunteers, Lewy Body Dementia
Clinical Study IdentifierTX249100
Last Modified on15 September 2020

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Alzheimer's Disease or Mild Cognitive Impairment or Lewy Body Dementia or Frontotemporal Dementia or *Healthy Volunteers?
You could be eligible for this study if
You either
Have mild cognitive impairment; or
Have young-onset Alzheimer’s (starting before the age of 65); or
Have frontotemporal dementia; or
Have Lewy body dementia; or
Are 65 or older, healthy, and have normal cognition
You have a ‘study partner’—a family member, friend, or caregiver—who would be willing to come with you on study visits and to answer questions about you
You may not be eligible for this study if
You have a significant medical, neurological, or psychiatric condition, including cancer, stroke, diabetes, major depression, bipolar disorder, or schizophrenia
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How to participate?

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What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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