This study is looking for people with mild cognitive
impairment, young-onset Alzheimer’s, frontotemporal dementia, or Lewy body
dementia. The study is also looking for cognitively-normal people over the age
of 65, as a comparison. The study will follow the progression of various
dementias to help with early detection, accurate diagnosis, and options for
At the start of the study, you will have two
study visits. Each visit will take 4-6 hours.
-You will do cognitive testing.
-You will answer questions about your mood,
sleep, and habits.
-You will have a medical exam.
-You will give a blood sample.
-You will give a spinal fluid sample.
-You will have a brain scan (described below).
During the study, you will visit the study
center once per year. Some or all of the study-start activities will be
The study will continue for the rest of your
After your death, your brain will examined under
Study activities may include:
-Doing cognitive testing and answering questions
about your mood, sleep, and habits, which may be in the form of interview-style
conversations, paper-and-pencil questionnaires, computer tests, and/or other
-Having a medical exam.
-Having a sample of blood taken from your arm
vein, using a needle.
-Having a sample of spinal fluid taken from your
lower back (spine), using a needle. This is also known as a lumbar puncture or
-Having a brain scan (described below).
-Donating your brain to science after your
Treatment or experiment details:
-The brain scan is an MRI. For this, you will
lie inside the scanning machine for about an hour while it takes a 3D image of
-Brain donation involves having an autopsy after
-There is no treatment or experiment being
tested in this study.
-As a participant in this study, you will
receive yearly feedback about your cognitive testing and your overall health.
You will also have access to a social worker, quality of life programs, and
education events. You will also have the opportunity to learn about other
related research studies.
You could be eligible for this study if:
-Have mild cognitive impairment; or
-Have young-onset Alzheimer’s (starting before
the age of 65); or
-Have frontotemporal dementia; or
-Have Lewy body dementia; or
-Are 65 or older, healthy, and have normal
You have a ‘study partner’—a family member,
friend, or caregiver—who would be willing to come with you on study visits and
to answer questions about you.
You may not be eligible for this study if:
-You have a significant medical, neurological,
or psychiatric condition, including cancer, stroke, diabetes, major depression,
bipolar disorder, or schizophrenia.