Dementia with Lewy Bodies Consortium.

Updated on 21 July 2021


The purpose of this study is to collect clinical information, brain imaging scans, and biological samples from people that have dementia with Lewy bodies. This information will help researchers gain a better understanding of the biology behind LBD.


Study schedule: 
-There will be six study visits: two in the first year, and one per year after that. 
Each study visit will involve:
-Having a medical exam.
-Doing cognitive tests.
-Giving a blood sample.
-Giving a sample of spinal fluid.
-Having brain scans (described below).
Additionally, you will be asked to agree to donate your brain to science after your death.

Study activities may include:
-Having a medical exam.
-Doing cognitive tests, which may be in the form of interview-style conversations, paper-and-pencil questionnaires, computer tests, and/or other activities.
-Having a sample of blood drawn from your arm vein, using a needle.
-Having a sample of spinal fluid drawn from your lower back (spine), using a needle. This is also known as a lumbar puncture or a spinal tap.
-Having brain scans (described below).
-Having injections as a standard part of the brain scan procedure.
-Agreeing to donate your brain to science after your death.

Treatment or experiment details: 
-One of the brain scans is an MRI. For this, you will lie inside the scanning machine for about an hour while it takes a 3D image of your brain.
-The other brain scan is a DaT scan. For this, you will have an injection in your arm vein, and then lie inside the scanning machine for about an hour while it takes a 3D image of your brain. The injection makes brain structures that are associated with Parkinson’s disease visible on the scanner.
-Brain donation involves having an autopsy after death. Then, your brain will examined under a microscope. 
-There is no treatment or experiment being tested in this study.
Additional details:

Condition Lewy Body Dementia, Parkinson's with Dementia
Clinical Study IdentifierTX249061
Last Modified on21 July 2021


How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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