At the start of the study:
-You will do cognitive tests.
-You will answer questions about your family history and health status.
-You will have a medical exam.
-You will give a blood sample.
-You may give a spinal fluid sample.
You may have a brain scan (described below).
-During the study, you will repeat the study-start activities once a year.
-The study activities will require one or two visits to the study center each
-You will consider whether to participate in other research studies for which
you may qualify.
-You will consider whether to donate your brain to science after your death.
-The study will end after about ten years.
Study activities may include:
-Doing cognitive tests and answering questions about your family history and
health status. This may be in the form of interview-style conversations,
paper-and pencil questionnaires, computer tests, and/or other activities.
-Having a medical exam.
-Having a sample of blood drawn from your arm vein, using a needle.
-Having a sample of spinal fluid drawn from your lower back (spine), using a
needle. This is also known as a lumbar puncture or a spinal tap.
-Having a brain scan (described below).
-Considering whether to participate in other research studies.
-Considering whether to donate your brain to science after your death.
Treatment or experiment details:
-The brain scan is an MRI. For this, you will lie inside the scanning machine
for about an hour while it takes a 3D image of your brain.
-There is no experiment or treatment being tested in this study.
-The study is interested in the ways that brain function changes over time in
various forms of dementia.
-There is no cost for participating in the study. Free parking will be provided
for study visits.
-Visits take place at
UCSF’s Memory and Aging Center at the Mission Bay campus. In response to
COVID-19, some parts of the study may be done remotely via Telehealth.