Last updated on August 2020

Emergency Department-Initiated Buprenorphine Validation Network Trial


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Opioid Use Disorder
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

RCT Component:

Inclusion Criteria:

  1. Be 18 years or older
  2. Treated in the ED during study screening hours
  3. Meet DSM-5 (Diagnostic and Statistical Manual) diagnostic criteria for moderate to severe OUD
  4. Have a COWS score of > 8
  5. Have a urine toxicology test that is positive for opioids (opiates, oxycodone, buprenorphine). Patients with urines that are only positive for fentanyl will be eligible if their clinical history and physical exam are consistent with opioid use and they meet DSM-5 criteria for moderate to severe OUD.
  6. Able to speak English sufficiently to understand the study the study procedures and provide written informed consent to participate in the study. (Exception may be made if sites with large population of Spanish speaking patients are accepted for participation in the study and study materials are translated into Spanish. Translated study materials will be reviewed and approved by the Institutional Review Board) IRB of record prior to use.)

Exclusion Criteria:

  1. Have urine toxicology test that is positive for methadone
  2. Be pregnant as determined by human chorionic gonadotropin (hCG) testing at the index ED visit
  3. Have a medical or psychiatric condition that requires hospitalization at the index ED visit, prior to randomization
  4. Be actively suicidal or severely cognitively impaired precluding informed consent
  5. Present from an extended care facility (e.g., skilled nursing facility)
  6. Require continued prescription opioids for a pain condition
  7. Be a prisoner or in police custody at the time of index ED visit
  8. Be currently (anytime within the past 14 days) enrolled in formal addiction treatment, including by court order. Patients enrolled in formal addiction who are not receiving MOUD are eligible
  9. Be unable to provide reliable locator information including 2 contact numbers in addition to their own
  10. Be unwilling to follow study procedures (e.g., unwilling to provide permission to contact referral provider/program or unavailable for the follow-up assessments)
  11. Have prior enrollment in the current study component

Ancillary Component:

Inclusion Criteria:

  1. Be 18 years or older
  2. Treated in the ED during study screening hours
  3. Meet DSM-5 diagnostic criteria for moderate to severe opioid use disorder
  4. Have a COWS <8
  5. Have a urine toxicology test that is positive for opioids (opiates, oxycodone, or buprenorphine). Patients with urines that are only positive for fentanyl will not be eligible unless urine toxicology testing is performed with a method approved for clinical use
  6. Be able to speak English sufficiently to understand the study procedures and provide written informed consent to participate in the study

Exclusion Criteria:

  1. Have an index ED visit due to opioid overdose
  2. Have a urine toxicology test that is positive for methadone
  3. Be pregnant as determined by human chorionic gonadotropin (hCG) testing at the index ED visit
  4. Have a medical or psychiatric condition that requires hospitalization at the index ED visit, prior to enrollment
  5. Be actively suicidal or severely cognitively impaired precluding informed consent
  6. Present from an extended care facility (e.g., skilled nursing facility)
  7. Require continued prescription opioids for a pain condition
  8. Be a prisoner or in police custody at the time of index ED visit
  9. Be currently (anytime within the past 14 days) enrolled in formal addiction treatment, including by court order. Patients enrolled in formal addiction treatment but are not receiving MOUD are eligible
  10. Be unable to provide reliable locator information including 2 contact numbers in addition to their own
  11. Be unwilling to follow study procedures (e.g., unwilling to provide permission to answer daily assessments until day 7)
  12. Have prior enrollment in the current study

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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