Anti-IL6 and Corticosteroid Monotherapy vs Combination in COVID-19

  • STATUS
    Recruiting
  • participants needed
    860
  • sponsor
    King Faisal Specialist Hospital & Research Center
Updated on 1 August 2021
interleukin-6
pneumonia
cytokines
covid-19
SARS

Summary

The cytokine storms mediated by over production of proinflammatory cytokines have been observed in a large population of critically ill patients infected with COVID-19. Patients diagnosed with cytokine storms progress to cardiovascular collapse, multiple organ dysfunction and death rapidly. Therefore, early identification, treatment and prevention of the cytokine storms are of crucial importance for the patients. Immuomedulator such as interleukin-6 (IL-6) antagonist, emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms recently. In this study, we aimed to evaluate the safety and efficacy of anti-IL6 alone vs anti-IL6 corticosteroid combination in patients with COVID-19 pneumonia

Description

This study will provide further insight whether anti-IL6 alone provide same efficacy and clinical outcome with reasonable side effects profile compared to anti-IL6 + corticosteroid and might serve as a corticosteroid sparing agents in COVID-19 patient with cytokine storms. Data elements will be retrieved from VIRUS registry which is a prospective, non-interventional, multi-center, multi-national observational cross sectional study

Details
Condition Coronavirus Infection, Critical Illness, Coronavirus, Corona Virus Infection, Cytokine Release Syndrome, critically ill
Treatment Interleukin 6 (IL6) Antagonist, Interleukin 6 (IL6) Antagonist and corticosteroids, corticosteroid alone
Clinical Study IdentifierNCT04486521
SponsorKing Faisal Specialist Hospital & Research Center
Last Modified on1 August 2021

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