The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 in Children With Henoch-sch nlein Purpura

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    The First Hospital of Jilin University
Updated on 22 October 2021
Accepts healthy volunteers


The study aims to explore the therapeutic value and mechanism of Interleukin-2 on children with Henoch-schnlein purpura.


The investigators designed a single center, open-label, prospective study that routinely administered low-dose IL-2 therapy to monitor the improvement of clinical and laboratory parameters to explore its efficacy and to observe changes in immune cell subsets and cytokines.For all patients,rhIL-2(500,000 unit per square meter) infusions seven days;recurrent patients were applied again for 7 days;patients who were diagnosed HSPN were treated on a routine basis for 7 consecutive days, and then once every two week for 3months.

Condition Allergic Purpura
Treatment IL-2
Clinical Study IdentifierNCT04387942
SponsorThe First Hospital of Jilin University
Last Modified on22 October 2021


Yes No Not Sure

Inclusion Criteria

age <18 years old
meet the EULAR/PRINTO/PRES for the diagnosis of HSP
HIV negative;Negative for HBV and HCV

Exclusion Criteria

heart failure (cardiac function grade III NYHA)
liver insufficiency (upper limit of normal range of transaminase > 2 times)
renal insufficiency (creatinine clearance 30ml/min)
acute or severe infections such as bacteremia and sepsis
malignant tumor
high-dose steroid pulse therapy or intravenous injection of glucocorticoids in the last 1 month
mental disorders or any other chronic illness or substance abuse may interfere with the ability to comply with agreements or provide information
Intestinal ischemia or perforated gastrointestinal bleeding requires surgery
Inability to comply with IL-2 treatment regimen
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