Last updated on July 2020

Effect on HIV Medications on EPC Cells

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: HIV Infections | Acquired Immune Deficiency Syndrome (AIDS - Pediatric) | AIDS | AIDS and AIDS related infections | HIV infection
  • Age: Between 40 - 70 Years
  • Gender: Male

Inclusion Criteria:

  1. Male only (as gender variation of progenitor cells along with effect of estrogen, may lead to difficulty in data interpretation), Age above 40, but less than 70 years,
  2. Body Mass Index (BMI) between 25.0-39.9 (both inclusive)
  3. eGFR 50 mL/min/1.73 m2 by MDRD.

Exclusion Criteria:

  1. Uncontrolled hyperglycemia with random blood glucose >200 mg/dL (>13.3 mmol/L)
  2. Liver disease with ALT, AST or ALP x3 ULN
  3. Subjects with HCV and HBV and detectable HCV RNA or HBV DNA
  4. GFR <50 mL/min/1.73 m2 by MDRD
  5. Prior surgery with chronic malabsorption (eg, bariatric) in prior 1 year
  6. Clinically significant RBC disorders such as hemoglobinopathies
  7. Chronic use of anti-inflammatory drugs for the last 3 months
  8. On statin medications (ASCVD score less than or equal to 7.5%)
  9. Use of consistent long-term steroid medication (oral, inhaled, injected) in last 1 month
  10. Treatment with a strong cytochrome P450 3A4 (CYP34A) or P-gp inducer (ie:Rifampin)
  11. Active smokers, Active wounds or recent surgery within 1 month
  12. Untreated hyper/hypothyroidism
  13. Implanted devices (eg. Pacemaker) that may interact with Tanita scale
  14. Any other clinical condition that would jeopardize patient safety while participating
  15. Women who are pregnant or breastfeeding
  16. Chronic or persistent alcohol or drug abuse
  17. Hypertriglyceridemia above 500mg/dl.
  18. Prisoners or subjects who are involuntarily incarcerated
  19. Subjects who are compulsorily detained for treatment of either a psychiatric illness
  20. Participation in another trial with an investigational drug within 30 days prior to consent

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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