SubsTRate OxidatioN in Girls (STRONG)

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Pennington Biomedical Research Center
Updated on 29 April 2022
Accepts healthy volunteers


This study will examine race differences in total energy expenditure and respiratory quotient (RQ) during and after exercise, compared to a sedentary control condition, in adolescent girls who are classified as overweight. In addition, subjective appetite and objective energy intake will be measured throughout the assessment periods.


Aim 1: Measure 24-hour energy expenditure and its components (resting, activity, and sleep energy expenditure) and compare differences between African-American and White girls.

Hypothesis: Total, resting, and sleep energy expenditure will be lower in African-American relative to White girls. Activity energy expenditure will be equivalent per the study design.

Aim 2: Measure and compare substrate oxidation and associations with appetite (i.e., hunger, desire to eat) and energy intake between African-American and White girls.

Hypothesis: African-American girls will have a higher RQ at rest, during exercise, and following exercise, and RQ will be positively associated with subjective appetite ratings and energy intake.

Condition Overweight Adolescents
Treatment Acute exercise
Clinical Study IdentifierNCT04483921
SponsorPennington Biomedical Research Center
Last Modified on29 April 2022


Yes No Not Sure

Inclusion Criteria

Age 13-17 years, inclusive
Achieved menarche based on parent- and/or self-report
Overweight based on BMI percentile for age and sex (≥ 85th and < 95th)
Self-identification as non-Hispanic White or African-American
Willing to maintain current physical activity, sleep schedule, and dietary habits during the study
Willing to comply with study procedures

Exclusion Criteria

Contraindications to exercise testing as defined by the American College of Sports Medicine (i.e., medical history of cardiovascular, pulmonary, or physical conditions that affect the ability to exercise)
Food allergies
Dietary restrictions
Unwilling to consume study foods
History of polycystic ovary syndrome (PCOS)
Current amenorrhea or other menstrual cycle irregularities
Pregnant or currently breastfeeding
Current anemia
Use of medications affecting metabolism or sleep
Inability to properly or safely complete the study procedures per the investigators' discretion
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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